Alcohols and polyols
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- (1)
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- (1)
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- (1)
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- (1)
- (463)
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- (46)
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- (46)
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- (1)
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- (12)
- (145)
- (116)
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- (1)
- (1)
- (1)
- (1)
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- (1)
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- (1)
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- (1)
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- (2)
- (1)
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- (2)
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- (1)
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- (1)
- (36)
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- (1)
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- (1)
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- (37)
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- (8)
- (2)
- (2)
- (8)
- (7)
- (7)
- (2)
- (1)
- (1)
- (26)
- (1)
- (1)
- (1)
- (2)
- (1)
- (3)
- (4)
- (2)
- (1)
- (15)
- (12)
- (1)
- (2)
- (2)
- (7)
- (12)
- (1)
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- (24)
- (1)
- (8)
- (4)
- (1)
- (2)
- (1)
- (22)
- (2)
- (6)
- (5)
- (2)
- (1)
- (5)
- (3)
- (4)
- (24)
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- (3)
- (5)
- (14)
- (1)
- (1)
- (1)
- (11)
- (3)
- (2)
- (4)
- (11)
- (2)
- (6)
- (4)
- (1)
- (3)
- (6)
- (11)
- (5)
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- (1)
- (2)
- (11)
- (14)
- (7)
- (2)
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- (1)
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- (1)
- (2)
- (1)
- (10)
- (1)
- (2)
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- (4)
- (1)
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- (1)
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- (1)
- (1)
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- (10)
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- (2)
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- (1)
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- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC Mefuparib hydrochloride | 1449746-00-2 | 98.6% | 334.77 | 5 MG
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Mefuparib hydrochloride is an orally active, substrate-competitive, and selective inhibitor of PARP1/2, with IC50 values of 3.2 nM and 1.9 nM respectively. It is known to induce apoptosis and exhibits significant anticancer activity both in vitro and in vivo.
- Orally active.
- Substrate-competitive and selective PARP1/2 inhibitor.
- Induces apoptosis.
- Possesses prominent anticancer activity in vitro and in vivo.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC PRT062607 Hydrochloride | 1370261-97-4 | 98.07% | 429.91 | 50 MG
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PRT062607 Hydrochloride is an orally available Syk inhibitor that effectively inhibits inflammation and induces apoptosis. It demonstrates potent antitumor activity in tumor xenograft mouse models. This compound inhibits phosphorylation of ERK, AKT, and SYK in Ramos cells, and BLNK Tyr84 phosphorylation in a concentration-dependent manner.
- Inhibits B cell antigen receptor-mediated B cell signaling and activation
- Inhibits Fc receptor 1-mediated induced basophil degranulation
- Produces dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
- Prevents BCR-induced splenomegaly in mice
- Prevents Ramos tumor formation in mouse xenograft models
- Significantly inhibits NHL tumor growth in xenograft models
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Medchemexpress LLC Asenapine hydrochloride (Org 5222 hydrochloride) | 1412458-61-7 | 99.95% | 322.23 | 50 MG
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Asenapine hydrochloride (Org 5222) is an atypical antipsychotic primarily investigated for its role in schizophrenia and bipolar disorder research. It acts as a potent antagonist across a diverse range of receptors, including serotonin, adrenoceptors, dopamine, and histamine.
- Exhibits higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B, and D3 receptors relative to its D2 receptor affinity.
- Potent antagonist (pKB) at 5-HT1A (7.4), 5-HT1B (8.1), 5-HT2A (9.0), 5-HT2B (9.3), 5-HT2C (9.0), 5-HT6 (8.0), 5-HT7 (8.5), D2 (9.1), D3 (9.1), α2A (7.3), α2B (8.3), α2C (6.8), and H1 (8.4) receptors.
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Medchemexpress LLC Nevanimibe hydrochloride | 133825-81-7 | MFCD00899568 | 99.5% | 458.08 g/mol | C27H40ClN3O | 1 ML
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Nevanimibe hydrochloride is the hydrochloride salt of nevanimibe, a selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor supplied as a 10 mM solution in DMSO (1 mL) for in vitro research use.
- Selective ACAT1 inhibitor with low-nanomolar activity
- Supplied as a ready-to-use 10 mM solution in DMSO
- High purity (~99.5%) suitable for biochemical and cell-based assays
- Molecular weight 458.08 g/mol aids solution preparation calculations
- Available in solid and solution formats for flexibility in workflows
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Medchemexpress LLC AMXI-5001 hydrochloride | 00-00-0 | 98.1% | C25H21ClFN5O3 | 10MG
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AMXI-5001 hydrochloride is a research-grade small molecule described as a dual inhibitor of PARP1/2 and microtubule polymerization. It shows potent cellular activity against PARP and tubulin targets, with reported favorable metabolic stability and oral bioavailability, and is intended for preclinical anticancer research.
- Dual mechanism: inhibits PARP1/2 and tubulin polymerization.
- Potent PARP inhibition with low nanomolar IC50s and tubulin inhibition in the micromolar range.
- Orally bioavailable with favorable pharmacokinetic properties.
- Suitable for in vitro and in vivo anticancer studies.
- High purity for research applications.
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Medchemexpress LLC Aprindine hydrochloride | 33237-74-0 | 98.96% | C22H31ClN2 | 1 ML
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Aprindine hydrochloride | 33237-74-0 | 98.96% | C22H31ClN2 | 1 ML
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Medchemexpress LLC OTS186935 hydrochloride | 99.6% | 522.31 | 50 MG
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OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. It significantly inhibits tumor growth in mouse xenograft models without detectable toxicity and regulates the production of γ-H2AX in cancer cells.
- Potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM.
- Shows significant inhibition of tumor growth in mouse xenograft models.
- Does not exhibit any detectable toxicity in mouse xenograft models.
- Regulates the production of γ-H2AX in cancer cells.
- Inhibits A549 cell growth with an IC50 of 0.67 μM.
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Medchemexpress LLC Slm6031434 hydrochloride | 1897379-34-8 | 99.1% | 1 MG
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A selective sphingosine kinase 2 (SphK2) inhibitor supplied as the hydrochloride salt for research use. Solid, high-purity material characterized by molecular formula C22H31ClF3N5O2 and molecular weight 489.96 Da.
- Selective sphingosine kinase 2 inhibitor for biochemical and cellular studies.
- Hydrochloride salt form, supplied as a solid powder.
- High purity (reported 99.1%), suitable for research applications.
- Soluble in water at approximately 40 mg/mL with ultrasonic warming if required.
- Recommended storage: long-term in solvent at -80°C, short-term at -20°C, sealed and away from moisture.
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Medchemexpress LLC Akalumine (hydrochloride) | 2558205-28-8 | 99.92% | 338.85 | 25 MG
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AkaLumine hydrochloride is a D-luciferin analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. It emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc, offering high tissue-penetration and increased detection sensitivity for deep-tissue targets. It is intended for research use only and not for sale to patients.
- D-luciferin analogue
- Km of 2.06 μM for recombinant firefly luciferase protein
- Emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc
- High tissue-penetration
- Increases detection sensitivity from deep-tissue targets
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Medchemexpress LLC Berubicin hydrochloride | 293736-67-1 | 95.1% | 670.10 | 1 MG
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Berubicin hydrochloride is an analog of Doxorubicin that can cross the blood-brain barrier. It inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). This product exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. It can be used in the study of tumors related to the nervous system.
- Crosses the blood-brain barrier
- Inhibits P-gp and MRP1-mediated efflux
- Suppresses glioblastoma multiforme (GBM)
- Activates nuclear factor κB (NF-κB)
- Induces apoptosis in neuroblastoma cells
- More potent activity than Doxorubicin in activating NF-κB and inhibiting DNA synthesis
- Prolongs survival time in intracranial orthotopic glioma models in mice
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Medchemexpress LLC Ladostigil hydrochloride | 209394-18-3 | 99.9% | 308.80 g/mol | C16H21ClN2O2 | 50 MG
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Ladostigil hydrochloride is the hydrochloride salt of ladostigil, an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase. It exhibits neuroprotective, antioxidant, and anti-inflammatory properties and is used as a research reagent in studies of neurodegeneration, depression, and Alzheimer's disease.
- Dual cholinesterase and monoamine oxidase inhibitor
- Neuroprotective, antioxidant, and anti-inflammatory activity
- Hydrochloride salt for improved solubility
- Click-chemistry compatible (contains an alkyne group)
- High purity verified by RP-HPLC, suitable for research
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Medchemexpress LLC Etifoxine hydrochloride | 56776-32-0 | 99.8% | 337.24 | 10 MM 1 ML
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Etifoxine hydrochloride is a non-benzodiazepine GABAergic compound. It acts as a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. It has demonstrated anxiolytic and anticonvulsant properties in rodents.
- Acts as a positive allosteric modulator of GABAA receptors.
- Demonstrates anxiolytic properties.
- Demonstrates anticonvulsant properties.
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Medchemexpress LLC Epz004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 5 MG
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EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. It reduces the levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression.
- Selectively inhibits the proliferation of MLL rearrangement cells
- Promotes the differentiation and subsequent apoptosis of leukemia cells
- Can be utilized for leukemia research
- Potent, concentration-dependent inhibition of DOT1L enzyme activity with an IC50 of 400±100 pM
- Remarkable selectivity for DOT1L over other HMTs
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Medchemexpress LLC Amsacrine hydrochloride | 54301-15-4 | MFCD07799963 | 99.9% | 429.92 g/mol | C21H20ClN3O3S | 5 MG
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Amsacrine hydrochloride is a topoisomerase II inhibitor supplied as a research-grade analytical standard. It intercalates DNA and stabilizes topoisomerase II-DNA cleavage complexes, making it suitable for biochemical assays and cell biology studies of DNA damage, cell cycle, and autophagy. Available as a solid and as a DMSO solution, the material is characterized for consistent analytical performance.
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Medchemexpress LLC Indotecan (hydrochloride) | 1228035-68-4 | 99.8% | 514.95 | 25 MG
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Indotecan hydrochloride, an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor. It has IC50s of 300, 1200, and 560 nM for P388, HCT116, and MCF-7 cell lines, respectively. This compound prevents the relaxation of supercoiled DNA and can be utilized for research on visceral leishmaniasis.
- Potent Topoisomerase I inhibitor.
- Effective in preventing relaxation of supercoiled DNA.
- Can be used for research on visceral leishmaniasis.
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